Ethyl 2-bromobenzoate → Ethyl 2-[4-(3,3-diphenyl-1-propyl)piperazin-1-yl]benzoate

HRID 1796750Notes

Reaction equation

HRID 1796750 reaction equation
Br[C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].[C:13]1([CH:19]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:28]1([CH:19]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:20][CH2:21][N:22]2[CH2:23][CH2:24][N:25]([C:2]3[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=3[C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH2:26][CH2:27]2)[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1

Participants

3

Reactant 2

HCID 80186Ethyl 2-bromobenzoateHCID 10356330N-3,3-Diphenylpropylpiperazine

Product 1

HCID 22180457Ethyl 2-[4-(3,3-diphenyl-1-propyl)piperazin-1-yl]benzoate

Procedure

Step (c) of Example 75 was repeated, except that ethyl 2-bromobenzoate and 4-(3,3-diphenyl-1-propyl)piperazine were used. Thus, ethyl 2-[4-(3,3-diphenyl-1-propyl)piperazin-1-yl]benzoate was prepared.

Sources & evidence

ORD record
ord-61eab7634d7348a0afcbe96d1388c410
Source dataset
uspto-grants-2006_04
Patent number
US07030120B2

Reaction notes

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