tert-Butyl piperazine-1-carboxylate → Ethyl 3-methyl-2-[4-(tert-butoxycarbonyl)piperazin-1-yl]isonicotinate

HRID 1796761Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1796761
Cl[C:2]1[C:3]([CH3:13])=[C:4]([CH:10]=[CH:11][N:12]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6].[C:14]([O:18][C:19]([N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)=[O:20])([CH3:17])([CH3:16])[CH3:15]>>[CH3:13][C:3]1[C:2]([N:24]2[CH2:23][CH2:22][N:21]([C:19]([O:18][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:20])[CH2:26][CH2:25]2)=[N:12][CH:11]=[CH:10][C:4]=1[C:5]([O:7][CH2:8][CH3:9])=[O:6]

Komponenten

3

Edukt 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 2762478Ethyl 2-chloro-3-methylisonicotinate

Produkt 1

HCID 22180458Ethyl 3-methyl-2-[4-(tert-butoxycarbonyl)piperazin-1-yl]isonicotinate

Versuchsvorschrift

Step (i) of Example 106 was repeated, except that the compound prepared in step (a) of Example 109 was used instead of 3-bromo-7,8-dihydro-6H-1,6-naphthyridin-5-one and 1-tert-butoxycarbonylpiperazine was used instead of 3,3-diphenyl-1-propylpiperazine. Thus, ethyl 3-methyl-2-[4-(tert-butoxycarbonyl)piperazin-1-yl]isonicotinate was obtained.

Quellen und Nachweise

ORD-Eintrag
ord-d0fb6cffaf0945b2b783085361b27dac
Quelldatensatz
uspto-grants-2006_04
Patentnummer
US07030120B2

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