Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Potassium bisulfate | HCID 516920 | — |
| Reactant | tert-Butyl [(2R)-1-hydroxy-4-(methylsulfanyl)butan-2-yl]carbamate | HCID 44593821 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 75487703 | HCID 75487703 | 100.2% |
Reaction Steps
A solution of Example 1A (9.05 g, 38.5 mmol), sulfur trioxide pyridine complex (30.64 g, 192.5 mmol), and triethylamine (26.8 mL, 192.5 mmol) in DMSO (30 mL) was stirred at ambient temperature for 30 minutes, cooled to 0° C., treated sequentially with water (20 mL) and saturated aqueous KHSO4 (120 mL), and extracted with ethyl acetate. The extract was washed sequentially with saturated aqueous KHSO4 and brine, dried (MgSO4), filtered, and concentrated to provide the desired product (9.00 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07030262B2 |
|---|
| Source dataset | uspto-grants-2006_04 |
|---|
| ORD ID | ord-2976f0f48d854573bc2dbe4a8a6fb534 |
|---|
| Source note | uspto-grants-2006_04 |
|---|
