HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → 2-[(3-Bromo-4-fluoro-phenyl)-pyrrolidin-1-yl-methyl]-1-(4-fluoro-phenyl)-1H-pyrrole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 3-Bromo-4-fluorobenzaldehyde | HCID 173604 | — |
| Reactant | N-(4-fluorophenyl)pyrrole | HCID 727844 | — |
| Reactant | 1-(3-Bromo-4-fluoro-benzylidene)-pyrrolidinium chloride | HCID 17912294 | — |
| Product | 2-[(3-Bromo-4-fluoro-phenyl)-pyrrolidin-1-yl-methyl]-1-(4-fluoro-phenyl)-1H-pyrrole | HCID 10180197 | — |
Reaction Steps
The preparation was carried out in accordance with general synthesis instructions 4 from 1-(4-fluoro-phenyl)-1H-pyrrole and 1-(3-bromo-4-fluoro-benzylidene)-pyrrolidinium chloride, which had been prepared in accordance with example 4 from 3-bromo-4-fluorobenzaldehyde and pyrrolidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07034018B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-6961dfabf70a4d53aeb67fb677994b3e |
| Source note | uspto-grants-2006_04 |