反应详情

To a cooled (ice/H2O) solution of 2.76 g of ethyl 4-iodobenzoate (prepared as described in Step 1) in 10 ml of anhyd. Et2O was added, over a 5 minutes period, 26.5 ml of 1.52M CH3MgBr/Et2O solution. The mixture was stirred at ice bath temperature for 2.5 hours and then quenched by slow addition of 6 ml of H2O. The reaction mixture was filtered and the solid residue rinsed with ether. The combined filtrates were dried over MgSO4 and concentrated under vacuum to provide the title compound as a clear yellowish liquid.

1. customquenched by slow addition of 6 ml of H2O
2. filtrationThe reaction mixture was filtered
3. washthe solid residue rinsed with ether
4. dry with materialThe combined filtrates were dried over MgSO4
5. concentrationconcentrated under vacuum