Phosphorus sulfide (P2S5) → HCID 178458289, compound

HRID 1796969Notes

Reaction equation

HRID 1796969 reaction equation
P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:2].CN1CCN(S([C:25]2[CH:26]=[CH:27][C:28]([O:45][CH2:46][CH2:47][CH3:48])=[C:29]([C:31]3[NH:39][C:38]4[C:37](=O)[NH:36][C:35](=[O:41])[N:34]([CH2:42][CH2:43][CH3:44])[C:33]=4[N:32]=3)[CH:30]=2)(=O)=O)CC1>N1C=CC=CC=1>[CH2:46]([O:45][C:28]1[CH:27]=[CH:26][CH:25]=[CH:30][C:29]=1[C:31]1[NH:39][C:38]2[C:37]([SH:2])=[N:36][C:35](=[O:41])[N:34]([CH2:42][CH2:43][CH3:44])[C:33]=2[N:32]=1)[CH2:47][CH3:48]

Participants

4

Reactant 2

HCID 14817Phosphorus sulfide (P2S5)HCID 22174681HCID 22174681, compound

Product 1

HCID 178458289HCID 178458289, compoundYield 129.2%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Phosphorus pentasulphide (0.7 g, 3.1 mmol) was added portionwise to a stirred suspension of 8-[5-(4-methylpiperazine-1-sulfonyl)-2-propoxyphenyl]-3-propyl-3,7-dihydropurine-2,6-dione (1.5 g, 23.3 mmol) in pyridine (15 mL) and the resulting mixture stirred under reflux for 3 hours, then evaporated under reduced pressure to give crude 8-(2-propoxyphenyl)-3-propyl-6-mercapto-3,7-dihydropurin-2-one (1.38 g) which was used directly in the next step.

Workup

  1. temperatureunder reflux for 3 hours
  2. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-141c5bc0f5b04819949db50dfa226530
Source dataset
uspto-grants-2006_04
Patent number
US07034016B2

Reaction notes

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