HCID 68967246, compound → 2-Methyl-2-(piperazin-1-yl)propan-1-ol

HRID 1796975Notes

Reaction equation

HRID 1796975 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][N:14]([C:17]([CH3:21])([CH3:20])[CH2:18][OH:19])[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>CO.[Pd]>[CH3:21][C:17]([N:14]1[CH2:13][CH2:12][NH:11][CH2:16][CH2:15]1)([CH3:20])[CH2:18][OH:19]

Participants

4

Reactant 1

HCID 68967246HCID 68967246, compound

Product 1

HCID 120525542-Methyl-2-(piperazin-1-yl)propan-1-olYield 98%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 4-(2-hydroxy-1,1-dimethylethyl)piperazine-1-carboxylic acid benzyl ester (3.0 g, 10.3 mmol) in methanol (70 mL) and palladium on charcoal (0.5 g, 10%) was hydrogenated at room temperature at 40 p.s.i. overnight. The mixture was filtered through Celite and the filtrate evaporated under reduced pressure to give the title compound (1.55 g, 98%) as a white solid.

Workup

  1. customwas hydrogenated at room temperature at 40 p.s.i
  2. customovernight
  3. filtrationThe mixture was filtered through Celite
  4. customthe filtrate evaporated under reduced pressure

Sources & evidence

ORD record
ord-4c28b4a24d074699b1e7d2b2142151ea
Source dataset
uspto-grants-2006_04
Patent number
US07034016B2

Reaction notes

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