反应详情

A mixture of 4-(2-hydroxy-1,1-dimethylethyl)piperazine-1-carboxylic acid benzyl ester (3.0 g, 10.3 mmol) in methanol (70 mL) and palladium on charcoal (0.5 g, 10%) was hydrogenated at room temperature at 40 p.s.i. overnight. The mixture was filtered through Celite and the filtrate evaporated under reduced pressure to give the title compound (1.55 g, 98%) as a white solid.

1. customwas hydrogenated at room temperature at 40 p.s.i
2. customovernight
3. filtrationThe mixture was filtered through Celite
4. customthe filtrate evaporated under reduced pressure