Tartrate → HCID 85336788, compound

HRID 1796989Notes

Reaction equation

HRID 1796989 reaction equation
Cl[C:2]1[C:3]2[N:14]=[N:13][N:12]([C@@H:15]3[CH2:19][CH2:18][CH2:17][C@H:16]3[OH:20])[C:4]=2[N:5]=[C:6]([S:8][CH2:9][CH2:10][CH3:11])[N:7]=1.[CH3:21][O:22][C:23]1[CH:28]=[CH:27][C:26]([C@@H:29]2[CH2:31][C@H:30]2[NH2:32])=[CH:25][CH:24]=1.O[C@H]([C@@H](O)C([O-])=O)C([O-])=O>>[CH3:21][O:22][C:23]1[CH:24]=[CH:25][C:26]([CH:29]2[CH2:31][CH:30]2[NH:32][C:2]2[C:3]3[N:14]=[N:13][N:12]([CH:15]4[CH2:19][CH2:18][CH2:17][CH:16]4[OH:20])[C:4]=3[N:5]=[C:6]([S:8][CH2:9][CH2:10][CH3:11])[N:7]=2)=[CH:27][CH:28]=1

Participants

4

Reactant 3

HCID 119400TartrateHCID 10442008(1R,2S)-2-(4-methoxyphenyl)cyclopropanamineHCID 87885146(1r-trans)-2-[7-Chloro-5-(propylthio)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]cyclopentanol

Product 1

HCID 85336788HCID 85336788, compound

Procedure

Prepared using the product from step b) (0.15 g) and (1R,2S)-2-(4-methoxyphenyl)cyclopropanamine, (2R,3R)-2,3-dihydroxybutanedioate (1:1) (0.20 g) (prepared as described in WO 9905143) by the method of Example 1, step d). Purified by chromatography (SiO2, ethyl acetate:dichloromethane 1:9 as eluant) to afford the title compound (0.12 g).

Workup

  1. customPrepared
  2. customPurified by chromatography (SiO2, ethyl acetate:dichloromethane 1:9 as eluant)

Sources & evidence

ORD record
ord-c5b56798c67d49ebbb17861cd7ae333c
Source dataset
uspto-grants-2006_04
Patent number
US07034032B2

Reaction notes

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