Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Phenylpropionic acid → 1-(4-Hydroxypiperidin-1-yl)-3-phenylpropan-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Phenylpropionic acid | HCID 10296 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Benzenepropanoyl chloride | HCID 64801 | — |
| 반응물 | Piperidin-4-ol | HCID 79341 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 1-(4-Hydroxypiperidin-1-yl)-3-phenylpropan-1-one | HCID 22175162 | 39% |
반응 단계
This amine was synthesized in accordance with the method of Scheme 37. To 4 g (40 mmol) of 4-hydroxypiperidine in 20 mL of toluene was added phenylpropionyl chloride (derived from 6 g (40 mmol) of phenylpropionic acid in excess thionyl chloride). To the mixture was added excess 2N aqueous NaOH. After stirring 24 hours, the toluene layer was discarded and the aqueous phase was extracted with CH2Cl2, dried, and evaporated under vacuum to give 3.63 g (39%) of 1-(3-phenylpropionyl)-4-hydroxypiperidine (134). GC/MS indicated 100% purity with a molecular ion of 233.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07034035B2 |
| 출처 데이터셋 | uspto-grants-2006_04 |
| ORD ID | ord-6bbe7f7bc04640a7a2e7ea520760f651 |
| 출처 메모 | uspto-grants-2006_04 |