p-Bromobenzenesulfonyl chloride → 4-Bromobenzenesulfonamide

HRID 1797208Notes

Reaction equation

HRID 1797208 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.CO.[NH3:14]>CO>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:14])(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 7396p-Bromobenzenesulfonyl chlorideHCID 21705897Ammonia methanol

Product 1

HCID 696964-BromobenzenesulfonamideYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-Bromobenzenesulfonyl chloride (1.0 g, 3.9 mmol), methanol/ammonia solution (5 mL, excess), and methanol (5 mL) were mixed together in a 25 mL-single neck flask and stirred overnight under a nitrogen atmosphere. In the morning, the reaction was concentrated under reduced vacuum to yield intermediate title compound (1.13 g, 100%) as a white solid. This material was used without further purification. Ion spray M.S. 235.9 (M*).

Workup

  1. concentrationIn the morning, the reaction was concentrated under reduced vacuum

Sources & evidence

ORD record
ord-2045a4994a0f4f27945ab9fed6462d9a
Source dataset
uspto-grants-2006_04
Patent number
US07034045B1

Reaction notes

Loading…