HCID 23567019, compound → HCID 10221997, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of {4′-[1-fluoro-1-methyl-2-(propane-2-sulfonylamino)ethyl]-3-nitro-biphenyl-4-yl}-acetic acid (0.311 g, 0.71 mmol, prepared in example 48) dissolved in Ethanol (4.0 mL)/50% H2SO4 (3.0 mL) at ambient temperature then heated to 90° C. is added Zn (0.186 g, 2.84 mmol) in divided portions over 30 minutes. Heating and stirring is continued for 2 h after addition of the Zn. The mixture is allowed to cool to ambient temperature. It is then extracted (EtOAc) and the EtOAc is extracted with 5% NaHCO3, washed with brine, dried (MgSO4), filtered and the filtrate concentrated in vacuo. Chromatography of the residue (silica gel, EtOAc/hexane) provides the title compound.

Provenance & Evidence