Sodium hydride → HCID 9943663, compound

Participants

Reaction Steps

The reaction and work up was conducted as described in the preparation of compound 415. Starting materials were NaH (60% in oil, 0.08 g, 2 mmol) in dry THF (10 mL), 3,3,3-trifluoropropan-1-ol (0.23 g, 2 mmol), 2-bromo-benzylbromide (0.50 g, 2 mmol) and tetrabutylammonium iodide (0.74 g, 0.2 mmol). The crude product was purified by flash chromatography using EtOAc/petroleum ether 1 : 35 as the eluent to afford the title compound as a pale yellow oil.

Provenance & Evidence