p-Toluenesulfonic acid → 2-[2-(2-{2-[(2-Bromobenzyl)oxy]ethoxy}ethoxy)ethoxy]tetra hydro-2H-pyran

Participants

Reaction Steps

The compound was prepared and worked up as described in the preparation of compound 420. Starting compounds were compound 416 (2.82 g, 8.9 mmol) in 6 mL dry THF, 3,4-dihydro-2H-pyran (0.89 mL, 9.8 mmol) and p-toluenesulfonic acid (37 mg, 0.19 mmol). The crude product was purified by flash chromatography using EtOAc/petroleum ether 1:3 as the eluent to afford the title compound as a pale yellow oil.

Provenance & Evidence