2-Bromobenzyl bromide → 2-(2-Bromobenzyl)isoindoline-1,3-dione

Participants

Reaction Conditions

Reaction Steps

2-Bromobenzyl bromide (5.25 g, 21.0 mmol) was dissolved in dry DMF (200 mL) and potassium phthalimide (3.89 g, 21.0 mmol) was added. The suspension was stirred at 70° C. for 5 h. The mixture was cooled to room temperature and poured into ice water (200 mL). After 30 min the mixture was filtered and the crystalline compound was dried overnight. Recrystallisation from DCM/petroleum ether afforded the title compound as colourless crystals.

Provenance & Evidence