1,3-Propanediol → HCID 22174480, compound

Participants

Reaction Steps

The reaction and work up was conducted as described in the preparation of compound 415. Starting materials were NaH (60% in oil, 0.86 g, 22 mmol) in THF (80 mL), 1,3-propanediol (8.67 mL, 120 mmol), 2-bromobenzylbromide (5.0 g, 20 mmol) dissolved in 4 mL dry THF and tetrabutylammonium iodide (0.07 g, 0.2 mmol). The crude product was purified by flash chromatography using EtOAc/petroleum ether 1:1->2:1 as the eluent to afford the title compound as a pale yellow oil.

Provenance & Evidence