Imidazole → HCID 18706297, compound

Participants

Reaction Steps

To a solution of o-bromobenzyl alcohol (2.55 g, 13.6 mmol) and imidazole (1.36 g, 20 mmol) in CH2Cl2 (20 ml) was added triisopropylsilyl chloride (2.6 ml, 12 mmol) at RT. The obtained mixture was stirred at the same temperature for 1 h and then taken up to H2O. After phase separation, the aqueous phase was extracted twice with petroleum ether. The combined organic phases were dried over MgSO4 and concentrated in vacuo. The residue was purified by filtration through a short column of silica gel to give the title compound as a colorless liquid.

Provenance & Evidence