Bromotrimethylsilane → 2-{[2-({3-Chloro-4-[(2-methylphenyl)carbonyl]phenyl}amino)benzyl]amino}-2-oxoethylphosphonic acid

HRID 1797313Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1797313
[Cl:1][C:2]1[CH:3]=[C:4]([NH:17][C:18]2[CH:36]=[CH:35][CH:34]=[CH:33][C:19]=2[CH2:20][NH:21][C:22](=[O:32])[CH2:23][P:24](=[O:31])([O:28]CC)[O:25]CC)[CH:5]=[CH:6][C:7]=1[C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH3:16])=[O:9].C[Si](Br)(C)C>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([NH:17][C:18]2[CH:36]=[CH:35][CH:34]=[CH:33][C:19]=2[CH2:20][NH:21][C:22](=[O:32])[CH2:23][P:24](=[O:25])([OH:28])[OH:31])[CH:5]=[CH:6][C:7]=1[C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH3:16])=[O:9]

Komponenten

4

Edukt 2

HCID 76113BromotrimethylsilaneHCID 22174547Diethyl 2-{[2-({3-chloro-4-[(2-methylphenyl)carbonyl]phenyl}amino)benzyl]amino}-2-oxoethylphosphonate

Produkt 1

HCID 221745422-{[2-({3-Chloro-4-[(2-methylphenyl)carbonyl]phenyl}amino)benzyl]amino}-2-oxoethylphosphonic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Compound 175 (0.04 g, 0.075 mmol) was dissolved in dry CH2Cl2 (0.5 mL) under an argon atmosphere. Trimethylsilyl bromide (0.1 mL, 0.75 mmol) was added and the solution was kept at room temperature for 45 h. The solution was concentrated in vacuo and then co-concentrated with MeOH three times. This afforded the title compound as an orange oil.

Aufarbeitung

  1. concentrationThe solution was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-b66df8c1b569421ca97919348d8b141e
Quelldatensatz
uspto-grants-2006_04
Patentnummer
US07034015B2

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