Benzenesulfonyl chloride → N-(2-{[3-Chloro-4-(2-methylbenzoyl)phenyl]amino}phenyl)-benzenesulfonamide

Participants

Reaction Steps

To a cold (ice/water) solution of {2-chloro-4-[(2-aminophenyl)amino]phenyl}(2-methylphenyl)methanone (0.67 g, 2.0 mmol)(disclosed in WO 98/32730) in pyridine (10 mL) was added benzenesulfonyl chloride (0.32 mL, 2.5 mmol). The reaction mixture was warmed to room temperature. After stirring for 48 h, the reaction mixture was poured into ice water. The precipitate was filtered off, washed with water, and diethyl ether to afford the crude product. Crystallization from acetic acid afforded the title compound as a solid.

Provenance & Evidence