Succinimide → HCID 22174564, compound

HRID 1797329Notes

Reaction equation

HRID 1797329 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[CH3:23])=[O:16])=[C:11]([Cl:24])[CH:10]=2)=[C:4]([CH2:25][O:26][CH2:27][CH2:28]O)[CH:3]=1.[C:30]1(=[O:36])[NH:34][C:33](=[O:35])[CH2:32][CH2:31]1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[CH3:23])=[O:16])=[C:11]([Cl:24])[CH:10]=2)=[C:4]([CH:3]=1)[CH2:25][O:26][CH2:27][CH2:28][N:34]1[C:33](=[O:35])[CH2:32][CH2:31][C:30]1=[O:36]

Participants

3

Reactant 2

HCID 11439SuccinimideHCID 10227340[4-({4-Bromo-2-[(2-hydroxyethoxy)methyl]phenyl}amino)-2-chlorophenyl](2-methylphenyl)methanone

Product 1

HCID 22174564HCID 22174564, compound

Procedure

Compound 158 (47 mg, 0.1 mmol), succinimide (14 mg, 0.14 mmol) were treated as described in the preparation of compound 219. Purification was done by flash chromatography (petroleum ether/ethyl acetate 1:1) to provide the title compound as yellow oil.

Workup

  1. customPurification

Sources & evidence

ORD record
ord-952f44bbe40e4fa4a21af949f2ddf76b
Source dataset
uspto-grants-2006_04
Patent number
US07034015B2

Reaction notes

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