[4-({4-Bromo-2-[(2-hydroxyethoxy)methyl]phenyl}amino)-2-chlorophenyl](2-methylphenyl)methanone → HCID 21027097, compound

HRID 1797331Notes

Reaction equation

HRID 1797331 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[CH3:23])=[O:16])=[C:11]([Cl:24])[CH:10]=2)=[C:4]([CH2:25][O:26][CH2:27][CH2:28]O)[CH:3]=1.[C:30]([O:33][C@H:34]1[C@@H:39]([O:40][C:41](=[O:43])[CH3:42])[C:38](=[O:44])[NH:37][C:35]1=[O:36])(=[O:32])[CH3:31]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[CH3:23])=[O:16])=[C:11]([Cl:24])[CH:10]=2)=[C:4]([CH:3]=1)[CH2:25][O:26][CH2:27][CH2:28][N:37]1[C:38](=[O:44])[C@H:39]([O:40][C:41](=[O:43])[CH3:42])[C@H:34]([O:33][C:30](=[O:32])[CH3:31])[C:35]1=[O:36]

Participants

3

Reactant 2

HCID 10227340[4-({4-Bromo-2-[(2-hydroxyethoxy)methyl]phenyl}amino)-2-chlorophenyl](2-methylphenyl)methanoneHCID 16753700HCID 16753700, compound

Product 1

HCID 21027097HCID 21027097, compound

Procedure

Compound 158 (67 mg, 0.1 mmol) and 2,3-cis-diacetoxysuccinimide (30 mg, 0.14 mmol) were treated as described in the preparation of compound 219. Purification was done by flash chromatography (CH2Cl2/ethyl acetate 1:20) to provide the title compound as yellow oil.

Workup

  1. customPurification

Sources & evidence

ORD record
ord-38f2d3c403b34043a84362467a1d65e4
Source dataset
uspto-grants-2006_04
Patent number
US07034015B2

Reaction notes

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