HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylhydantoin → 3-(2-{[5-Bromo-2-({3-chloro-4-[(2-methylphenyl)carbonyl]phenyl}amino)benzyl]oxy}ethyl)-1-methylimidazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylhydantoin | HCID 69217 | — |
| Reactant | [4-({4-Bromo-2-[(2-hydroxyethoxy)methyl]phenyl}amino)-2-chlorophenyl](2-methylphenyl)methanone | HCID 10227340 | — |
| Product | 3-(2-{[5-Bromo-2-({3-chloro-4-[(2-methylphenyl)carbonyl]phenyl}amino)benzyl]oxy}ethyl)-1-methylimidazolidine-2,4-dione | HCID 22174553 | — |
Reaction Steps
Compound 158 (47 mg, 0.1 mmol) and methylhydantoin (16 mg, 0.14 mmol) were treated as described in the preparation of compound 219. Purification was done by flash chromatography (petroleum ether/ethyl acetate 1:1) to provide the title compound, which was impure. The product was further purified by preparative TLC (petroleum ether/ethyl acetate 1:1) to furnish the pure title compound as yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07034015B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-b81319042a5f42fbaab028742553cb25 |
| Source note | uspto-grants-2006_04 |