Potassium Hydroxide → 3-(4-Butoxy-3-methoxyphenyl)prop-2-enoic acid

Participants

Reaction Conditions

Reaction Steps

10 g (0.15 mol) potassium hydroxide were dissolved in a mixture of 200 ml methyl alcohol and 5 ml water. 4.85 g (18.35 mmol) methyl (2E)-3-(4-butoxy-3-methoxyphenyl)-2-propenoate was added. The reaction mixture was subsequently heated to 60° C. After 2.5 h the mixture was concentrated by evaporation. The residue was dissolved in 100 ml cold water and acidified to pH=1 with 13.5 ml hydrochloric acid 37 wt. %. The product was filtered off, washed with water and dried at 50° C. under vacuum to give 4.24 g (92%) (2E)-3-(4-butoxy-3-methoxyphenyl)-2-propenoic acid as white crystals.

Provenance & Evidence