Hydrochloric Acid → HCID 9944111, compound

Participants

Reaction Conditions

Reaction Steps

A solution of sodium borohydride (25.7 g) in 0.1N NaOH (202 mL) was added dropwise to a suspension of 2-methyl-1-(4-methylphenyl)-2-(2,3,5-trimethylphenoxy)-1-propanone (251.9 g) in methanol (2519 mL). The mixture was stirred at 35° C. for 3 hours. After the mixture was adjusted to pH 7 by addition of 1N HCl under ice-cooling, methanol was distilled off, followed by extraction with toluene (2015 mL). The extract was washed with water, and the solvent was distilled off to quantitatively obtain the title compound as an oil (253.7 g).

Provenance & Evidence