Hydrochloric Acid → HCID 22175736, compound

Participants

Reaction Steps

To a solution of tert-butyl(4-butoxy-7-fluoro-2-neopentyl-1-oxo-1,2-dihydro-3-isoquinolinyl)methylcarbamate (1.74 g, 4 mmol) in ethyl acetate (5 ml) was added a solution of 4N hydrogen chloride in ethyl acetate(5 ml), and the obtained solution was stirred at room temperature for 2 h. The reaction mixture was concentrated under reduced pressure and the precipitated crystals were, recrystallized from methanol-diisopropyl ether to give 3-(aminomethyl)-4butoxy-7-fluoro-2-neopentyl-1(2H)-isoquinolinone hydrochloride (1.42 g, 95.9%) as crystals.

Provenance & Evidence