Hydrochloric Acid → HCID 22175425, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 6-chloro-4-methoxy-2-methyl-1-oxo-1,2-dihydro-3-isoquinolinecarboxylate (1.03 g, 3.5 mmol) in tetrahydrofuran (10 ml) and ethanol (10 ml) was added 1N sodium hydroxide (5 ml). The obtained mixture was refluxed under stirring at 50° C. for 3 h. The reaction mixture was poured into water, acidified with 1N hydrochloric acid and extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The obtained crystals were recrystallized from ethyl acetate diethyl ether to give 6-chloro-4-methoxy-2-methyl-1-oxo-1,2-dihydro-3-isoquinolinecarboxylic acid (0.72 g, 77.4%) as crystals.

Provenance & Evidence