Water → HCID 22175431, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-{[6-chloro-4-(4-methoxyphenyl)-2-methyl-1-oxo-1,2-dihydro-3-isoquinolinyl]methyl}-1H-isoindole-1,3(2H)-dione (synthesized according to the method similar to that in Example 16(7)) (0.92 g, 2 mmol) in dichloromethane (10 ml) was added boron tribromide, (76 ml, 36 mmol) at 0° C. and the mixture was stirred at 0° C. for 1 h. The reaction mixture was poured into water and extracted with ethyl acetate. After washing the extract with water, the extract was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was recrystallized from tetrahydrofuran-diisopropyl ether to give 2-{[6chloro-4-(4-hydroxyphenyl)-2-methyl-1-oxo-1,2-dihydro-3-isoquinolinyl]methyl}-1H-isoindole-1,3(2H)-dione (0.83 g, 94.3%) as crystals.

Provenance & Evidence