HCID 22175634, compound → HCID 22175773, compound

Participants

Reaction Steps

A mixture of ethyl 3-[4-butoxy-6,7-dichloro-3-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-1-oxo-2 (1H)isoquinolinyl]propionate (1.36 g, 2.5 mmol) in 6N hydrochloric acid (15 ml) and acetic acid (15 ml) was refluxed with stirring for 2 h. The reaction mixture was concentrated under reduced pressure, and the residue was recrystallized from tetrahydrofuran-diisopropyl ether to give 3-[4-butoxy-6,7-dichloro-3-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-1-oxo-2(1H)-isoquinolinyl]propionic acid (1.08 g, 83.7%) as crystals.

Provenance & Evidence