Tetrahydrofuran → HCID 22175795, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-butoxy-6,7-dichloro-2-methyl-1-oxo-1,2-dihydro-3-isoquinolinealdehyde (0.98 g, 24 mmol) in tetrahydrofuran (20 mmol) was added 3N methylmagnesium bromide tetrahydrofuran solution (1.5 ml, 4.5 mmol) at 0° C. and the obtained mixture was stirred at 0° C. for 1 h. The reaction mixture was poured into water and extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate-n-hexane to give 4-butoxy-6,7-dichloro-3-(1-hydroxyethyl)-2-methyl-1(2H)-isoquinolinone (0.95 g, 92.2%) as crystals.

Provenance & Evidence