Thionyl Chloride → HCID 22175642, compound

Participants

Reaction Steps

To a solution of 6-bromo-3-hydroxymethyl-2-isobutyl-4-phenyl-1(2H)-isoquinolinone (8.7 g, 22.5 mmol) and pyridine (5 drops) in tetrahydrofuran (30 mL) and toluene (30 mL) was added thionyl chloride (3.4 mL, 47.3 mmol). The obtained mixture was stirred at room temperature for 3 h. The reaction mixture was concentrated, poured into water and extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 6-bromo-3-chloromethyl-2-isobutyl-4-phenyl-1(2H)-isoquinolinone (8.2 g, 90%) as crystals.

Provenance & Evidence