Hydrochloric Acid → HCID 22175368, compound

Participants

Reaction Steps

To a solution of 6-benzyloxycarbonylamino-3-tert-butoxycarbonylaminomethyl-2-isobutyl-4-phenyl-1(2H)-isoquinolinone (0.07 g, 0.13 mmol) in tetrahydrofuran (2 mL) was added a solution, of 4N hydrogen chloride in ethyl acetate (10 mL). The obtained solution was stirred at room temperature for 5 h. The reaction mixture was concentrated under reduced pressure and the residue was crystallized from diethyl ether to give 3-aminomethyl-6-benzyloxycarbonylamino-2-isobutyl-4-phenyl-1(2H)-isoquinolinone hydrochloride (0.05 g, 81%) as crystals.

Provenance & Evidence