Water → HCID 22176183, compound

Participants

Reaction Steps

A mixture of 6-amino-3-tert-butoxycarbonylaminomethyl-2-isobutyl-4-phenyl-1(2H)-isoquinolinone (synthesized according to the method similar to that in Example 111 (1)) (0.1 g, 0.24 mmol), acetyl chloride (38 mg, 0.48 mmol), sodium hydrogencarbonate (81 mg, 0.96 mmol), water (0.5 ml) and ethyl acetate (5 ml) was stirred at room temperature for 2 h. The reaction mixture was extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was crystallized from diisopropyl ether to give 6-acetylamino-3-tert-butoxycarbonylaminomethyl-2-isobutyl-4-phenyl-1(2H)-isoquinolinone (80 mg, 73%) as crystals.

Provenance & Evidence