Thionyl Chloride → HCID 22176328, compound

Participants

Reaction Steps

To a solution of 6-bromo-4-butoxy-2-cyclopropylmethyl-3-hydroxymethyl-1(2H)-isoquinolinone (5.70 g, 15 mmol) in toluene (50 mL) was added thionyl chloride (2.2 mL, 30 mmol). The obtained mixture was refluxed under heating for 2 h. The reaction mixture was poured into saturated aqueous sodium hydrogencarbonate solution, and extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 6-bromo-4-butoxy-3-chloromethyl-2-cyclopropylmethyl-1(2H)-isoquinolinone (5.72 g, 95.7%) as crystals.

Provenance & Evidence