5-Fluoro-6-(4-fluoro-benzylamino)-1,3-dihydro-indol-2-one → 2-[5-Fluoro-6-(4-fluoro-benzylamino)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-3-methyl-5-(2-piperidin-1-yl-ethyl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one

HRID 179751Notes

Reaction equation

HRID 179751 reaction equation
[CH3:1][c:2]1[c:3]([CH:20]=[O:21])[nH:4][c:5]2[c:6]1[C:7](=[O:19])[N:8]([CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1)[CH2:9][CH2:10]2.[F:22][c:23]1[cH:24][c:25]2[c:29]([cH:30][c:31]1[NH:32][CH2:33][c:34]1[cH:35][cH:36][c:37]([F:40])[cH:38][cH:39]1)[NH:28][C:27](=[O:41])[CH2:26]2>>[CH3:1][c:2]1[c:3]([CH:20]=[C:26]2[c:25]3[cH:24][c:23]([F:22])[c:31]([NH:32][CH2:33][c:34]4[cH:35][cH:36][c:37]([F:40])[cH:38][cH:39]4)[cH:30][c:29]3[NH:28][C:27]2=[O:41])[nH:4][c:5]2[c:6]1[C:7](=[O:19])[N:8]([CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1)[CH2:9][CH2:10]2

Participants

3

Reactant 2

HCID 592500565-Fluoro-6-(4-fluoro-benzylamino)-1,3-dihydro-indol-2-oneHCID 866376773-methyl-4-oxo-5-(2-piperidin-1-yl-ethyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine-2-carbaldehyde

Product 1

HCID 666070132-[5-Fluoro-6-(4-fluoro-benzylamino)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-3-methyl-5-(2-piperidin-1-yl-ethyl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one

Sources & evidence

ORD record
ord-5ee373b202ad4b82bd388cff5476341e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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