HCID 22175957, compound → HCID 22175412, compound

Participants

Reaction Steps

To a solution of 4 tert-butyl(4-butoxy-2-cyclopropylmethyl-6-hydroxymethyl-1-oxo-1,2-dihydro-3-isoquinolinyl)methylcarbamate (0.45 g, 3.5 mmol) in tetrahydrofuran (10 mL) was added manganese dioxide (0.12 g) and the mixture was stirred at room temperature for 12 h. Manganese dioxide was filtered off, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give tert-butyl(4-butoxy-2-cyclopropylmethyl-6-formyl-1-oxo-1,2-dihydro-3-isoquinolinyl)methylcarbamate (0.33 g, 76.7%) as crystals.

Provenance & Evidence