Hydrochloric Acid → HCID 22175287, compound

Participants

Reaction Steps

To a solution of tert-butyl[4-butoxy-2-isobutyl-6-(1,3-oxazol-5-yl)-1-oxo-1,2-dihydro-3-isoquinolinyl]methylcarbamate (0.28 g, 0.6 mmol) in ethyl acetate (5 mL) was added a solution of 4N hydrogen chloride in ethyl acetate (5 ml) and the obtained solution was stirred at room temperature for 1 h. The reaction mixture was concentrated under reduced pressure, and the precipitated crystals were recrystallized from methanol-diisopropyl ether to give 3-(aminomethyl)-4-butoxy-2-isobutyl-6-(1,3-oxazol-5-yl)-1(2H)-isoquinolinone hydrochloride (0.22 g, 91.7%) as crystals.

Provenance & Evidence