HCID 22176030, compound → HCID 22175254, compound

Participants

Reaction Steps

A suspension of tert-butyl[6-benzyloxy-4-(2-fluorophenyl)-2-isobutyl-1-oxo-1,2-dihydro-3-isoquinolinyl]methylcarbamate (3.98 g, 7.5 mmol) and 5% palladium carbon (1.5 g) in ethanol (50 mL) was stirred under a hydrogen atmosphere at room temperatures for 2 h. The catalyst was filtered off and the filtrate was concentrated under reduced pressure. The obtained crystals were recrystallized from tetrahydrofuran-diisopropyl ether to give tert-butyl[4-(2-fluorophenyl)-6-hydroxy-2-isobutyl-1-oxo-1,2-dihydro-3-isoquinolinyl]methylcarbamate (3.11 g, 94.2%) as crystals.

Provenance & Evidence