Potassium Carbonate → HCID 10270831, compound

Participants

Reaction Steps

(E)-3-[3-(Aminomethyl)-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-6-isoquinolinyl]-2-propenamide hydrochloride (Example 159 (6)) (0.13 g, 0.3 mmol) was dissolved in water (10 mL) and saturated aqueous potassium carbonate solution (10 mL) was added. The mixture was extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The precipitated crystals were recrystallized from ethyl acetate-diisopropyl ether to give (E)-3-[3-(aminomethyl)-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-6-isoquinolinyl]-2-propenamide (0.06 g, 54.5%) as crystals.

Provenance & Evidence