HCID 22175920, compound → HCID 22175870, compound

Participants

Reaction Steps

A suspension of tert-butyl(6-benzyloxy-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-3-isoquinolinyl)methylcarbamate (2.05 g, 4 mmol) and 5% palladium carbon (0.6 g) in tetrahydrofuran (10 mL) and ethanol (10 mL) was stirred under a hydrogen atmosphere at room temperature for 2 h. The catalyst was filtered off and the filtrate was concentrated under reduced pressure. The obtained crystals were recrystallized from ethyl acetate-diisopropyl ether to give tert-butyl(6-hydroxy-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-3-isoquinolinyl)methylcarbamate (1.56 g, 92.3%) as crystals.

Provenance & Evidence