Hydrochloric Acid → HCID 22175363, compound

Participants

Reaction Steps

To a solution of ethyl 6-benzyloxy-2-isobutyl-1-oxo-4-(4,4,4-trifluorobutoxy)-1,2-dihydro-3-isoquinolinecarboxylate (6.57 g, 13 mmol) in ethanol (50 mL) was added an aqueous solution (20 mL) of sodium hydroxide (2.08 g, 52 mmol). The obtained mixture was refluxed under heating for 12 h. The reaction mixture was poured into water acidified with 1N hydrochloric acid and extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium, sulfate and concentrated under reduced pressure. The obtained, crystals were recrystallized from ethyl acetate-n-hexane to give 6-benzyloxy-2-isobutyl-1-oxo-4-(4,4,4-trifluorobutoxy)-1,2-dihydro-3-isoquinolinecarboxylic acid (4.89 g, 78.7%) as crystals.

Provenance & Evidence