Chloride → HCID 22175557, compound

Participants

Reaction Steps

To a solution of tert-butyl[6-(2-amino-2-oxoethoxy)-2-isobutyl-4-(4,4,4-trifluorobutoxy)-1-oxo-1,2-dihydro-3-isoquinolinyl]methylcarbamate (0.18 g, 0.35 mmol) in ethyl acetate (5 mL) was added a solution of 4N hydrogen, chloride in ethyl acetate (5 mL) and the obtained solution was stirred at room temperature for 2 h. The reaction mixture was concentrated under reduced pressure, and the precipitated crystals were recrystallized from methanol-diisopropyl ether to give 2-[[3-(aminomethyl)-2-isobutyl-1-oxo-4-(4,4,4-trifluorobutoxy)-1,2-dihydro-6-isoquinolinyl]oxy]acetamide hydrochloride (0.15 g, 93.8%) as crystals.

Provenance & Evidence