Hydrochloric Acid → HCID 22175841, compound

Participants

Reaction Steps

To a suspension of methyl 6-benzyloxy-4-(4-chlorophenyl)-2-isobutyl-1-oxo-1,2-dihydro-3-isoquinolinecarboxylate (5.00 g, 10.5 mmol) in 1,4-dioxane (50 ml) was added an aqueous solution (20 ml) of lithium hydroxide monohydrate (1.32 g, 31.5 mmol). The obtained mixture was refluxed under heating for 24 h. The reaction mixture was poured into water, acidified with 1N hydrochloric acid and extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The obtained, crystals were recrystallized from tetrahydrofuran-n-hexane to give 6-benzyloxy-4-(4-chlorophenyl)-2-isobutyl-1-oxo-1,2-dihydro-3-isoquinolinecarboxylic acid (4.69 g, 96.7%) as crystals.

Provenance & Evidence