Lawesson's reagent → HCID 86592074, compound

Participants

Reaction Steps

To a suspension of 3-[[(tert-butoxycarbonyl)amino]methyl]-4-butoxy-2-isobutyl-1-oxo-1,2-dihydro-6-isoquinolinecarboxamide (0.44 g, 1 mmol) in toluene (20 ml) was added Lawesson's reagent (0.24 g, 0.6 mmol), and the mixture was refluxed under heating for 1 h. The reaction mixture was purified by silica gel column chromatography to give tert-butyl[6-(aminothiocarbonyl)-4-butoxy-2-isobutyl-1-oxo-1,2-dihydro-3-isoquinolinyl]methylcarbamate (0.18 g, 39.1%) as crystals.

Provenance & Evidence