Hydrochloric Acid → HCID 22175813, compound

Participants

Reaction Steps

Tert-butyl[4-butoxy-2-isobutyl-1-oxo-6-(1H-pyrrol-1-yl)-1,2-dihydro-3-isoquinolinyl]methylcarbamate (0.23 g, 0.5 mmol) was dissolved in a solution of 4N hydrogen chloride in ethyl acetate (5 ml) and the mixture was stirred at room temperature for 1 h. The reaction mixture was concentrated under reduced pressure and the obtained crystals were recrystallized from methanol-diethyl ether to give 3-(aminomethyl)-4-butoxy-2-isobutyl-6-(1H-pyrrol-1-yl)-1(2H)-isoquinolinone dihydrochloride (0.19 g, 95.0%) as crystals.

Provenance & Evidence