Hydrochloric Acid → HCID 135788476, compound

Participants

Reaction Steps

Tert-butyl[2-isobutyl-1-oxo-6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-4-phenyl-1,2-dihydro-3-isoquinolinyl]methylcarbamate (0.18 g, 0.37 mmol) was dissolved in ethanol (4 ml) and a solution (4 ml) of 4N hydrogen chloride in ethyl acetate was added. The mixture was stirred at room temperature for 30 min. The reaction mixture was concentrated under reduced pressure, and the residue was washed with diisopropyl ether (2 ml) and recrystallized from ethyl acetate-ethanol (20:1) to give 3-(aminomethyl)-2-isobutyl-6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-4-phenyl-1(2H)-isoquinolinone hydrochloride (0.12 g, 80%) as a colorless powder.

Provenance & Evidence