Hydrochloric Acid → HCID 135788480, compound

Participants

Reaction Steps

Tert-butyl[2-isobutyl-1-oxo-6-(5-oxo-4,5-dihydro-1,2,4-thiadiazol-3-yl)-4-phenyl-1,2-dihydro-3-isoquinolinyl]methylcarbamate (0.050 g, 0.10 mmol) was dissolved in tetrahydrofuran (3 ml) and a solution (2 ml) of 4N hydrogen chloride in ethyl acetate was added. The mixture was stirred at room temperature for 24 h. The reaction mixture was concentrated under reduced pressure and diisopropyl ether-ethyl acetate (2:1) was added to the residue to give 3-(aminomethyl)-2-isobutyl-6-(5-oxo-4,5-dihydro-1,2,4-thiadiazol-3-yl)-4-phenyl-1(2H)-isoquinolinone hydrochloride (0.041 g, 94%) as a pale-yellow powder.

Provenance & Evidence