Ammonium Hydroxide → HCID 22175497, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-bromo-2-isobutyl-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carbonitrile (16.0 g), sponge cobalt (manufactured by Kawaken Fine Chemicals Co., Ltd.; trademark: ODHT-60) (4 ml), 25% ammonium hydroxide (2 ml) and tetrahydrofuran. (80 ml) was stirred at 60° C. at a 1 MPa hydrogen pressure for 4 h and the catalyst was filtered off. The solvent was evaporated and acetonitrile (48 ml) was added to the residue. The mixture was heated to about 70° C. The obtained solution was cooled to 25° C. to give crystals, and water (80 ml) was added dropwise. The obtained mixture was cooled to around 5° C. and the mixture was stirred for 1 h. The precipitated crystals were collected by filtration to give the title compound (14.8 g, yield 91.4%).

Provenance & Evidence