Dimethyl Sulfoxide → HCID 9928326, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-(aminomethyl)-2-isobutyl-1-oxo-4-phenyl-1,2-dihydroisoquinoline-6-carbonitrile (20.0 g), 2N aqueous sodium-hydroxide solution (6 ml), dimethyl sulfoxide (100 ml) and water (40 ml) was stirred at an inner temperature of 85° C. for 30 min. The reaction mixture was cooled to 40° C., cooled to not higher than 5° C. and stirred for 1 h. The precipitated crystals were collected by filtration and washed twice with water (40 ml) to give the title compound (21.7 g) as pale yellow crystals.

Provenance & Evidence