Hydrochloric Acid → HCID 22176269, compound

Participants

Reaction Steps

Tert-butyl[6-(4-amino-1,3-thiazol-2-yl)-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-3-isoquinolinyl]methylcarbamate (0.14 g, 0.5 mmol) was dissolved in a solution of 4N hydrogen chloride in ethyl acetate (5 ml). The solution was stirred at room temperature for 1 h. The reaction was concentrated under reduced pressure, and the residue was crystallized from ethyl acetate to give 3-(aminomethyl)-6-(4-amino-1,3-thiazol-2yl)-2-isobutyl-4-phenyl-1(2H)-isoquinolinone dihydrochloride (0.13 g, 92.9%) as crystals.

Provenance & Evidence