Hydrochloric Acid → HCID 22176240, compound

Participants

Reaction Steps

Methyl 2-[(3-{[(tert-butoxycarbonyl)amino]methyl-}-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-6-isoquinolinyl)oxy]-2-methylpropanoate (0.16 g, 0.3 mmol) was dissolved in a solution of 4N hydrogen chloride in ethyl acetate (5 ml). The solution was stirred at room temperature for 1 h. The reaction was concentrated under reduced pressure, and the precipitated crystals were recrystallized from ethyl acetate-diisopropyl ether to give methyl 2-{[3-(aminomethyl)-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-6-isoquinolinyl]oxy}-2-methylpropanoate hydrochloride(0.10 g, 71.4%) as crystals.

Provenance & Evidence