Hydrochloric Acid → 3-(aminomethyl)-4-butoxy-2-isobutyl-6-[2-(1,3-thiazol-4-yl)ethyl]-1(2H)-isoquinolinone hydrochloride

Participants

Reaction Steps

Tert-butyl{4-butoxy-2-isobutyl-1-oxo-6-[2-(1,3thiazol-4-yl)ethyl]-1,2-dihydro-3-isoquinolinyl}methylcarbamate (0.16 g, 0.3 mmol) was dissolved in absolution of 4N hydrogen chloride in ethyl acetate (5 ml). The solution was stirred at room temperature for 1 h. The reaction was concentrated under reduced pressure to give 3-(aminomethyl)-4-butoxy-2-isobutyl-6-[2-(1,3-thiazol-4-yl)ethyl]-1(2H)-isoquinolinone hydrochloride (0.13 g, 92.9%) as an amorphous solid.

Provenance & Evidence